Serum-free Media Market

Global Serum-free Media Market Research Report Global Industry Analysis, Size, Share, Growth, Trends, Regional Analysis, Competitor Analysis and Forecast 2024-2032: By Product (CHO Media, HEK 293 Media, BHK Medium, Vero Medium, Stem Cell Medium, and Other Serum-free Media), By Application (Bioproduction, Vaccines Production, Tissue Engineering & Regenerative Medicine, and Cell and Gene Therapy), By End-user (Pharmaceutical & Biotechnology Companies, Research & Academic Institutes, and Others), and Region (North America, Europe, Asia-Pacific, and Rest of the World)

Biotechnology | February 2024 | Report ID: EMR00601 | Pages: 301

The global serum-free media market was valued at USD 1.62 billion in 2023 and is estimated to reach approximately USD 5.07 billion by 2032, at a CAGR of 13.5% from 2024 to 2032.

Serum-free media's release onto the market represents a substantial development in cell culture technology. Serum-free formulations offer a feasible substitute for conventional serum-containing medium, giving researchers and industrial users more control over the circumstances under which cells grow. This reduces variability and improves repeatability. This invention provides a more controlled and secure environment for cell culture, allaying worries about impurities originating from serum. The advent of serum-free media satisfies the changing needs of the biotechnology, pharmaceutical, and academic sectors, increasing efficiency and speeding advancement in numerous domains of life sciences. There is an increased demand for dependable and consistent cell culture systems.




Report Attribute


Estimated Market Value (2023)

1.62 Bn

Projected Market Value (2032)

5.07 Bn

Base Year


Forecast Years

2024 - 2032

Scope of the Report

Historical and Forecast Trends, Industry Drivers and Constraints, Historical and Forecast Market Analysis by Segment- By Product, By Application, By End-user, & Region

Segments Covered

By Product, By Application, By End-user, & Region

Forecast Units

Value (USD Billion or Million), and Volume (Units)

Quantitative Units

Revenue in USD million/billion and CAGR from 2024 to 2032

Regions Covered

North America, Europe, Asia Pacific, Latin America, and Middle East & Africa, and the Rest of World

Countries Covered

U.S., Canada, Mexico, U.K., Germany, France, Italy, Spain, China, India, Japan, South Korea, Brazil, Argentina, GCC Countries, and South Africa, among others

Report Coverage

Market growth drivers, restraints, opportunities, Porter’s five forces analysis, PEST analysis, value chain analysis, regulatory landscape, market attractiveness analysis by segments and region, company market share analysis, and COVID-19 impact analysis.

Delivery Format

Delivered as an attached PDF and Excel through email, according to the purchase option.


Global Serum-free Media Dynamics

The use of serum-free substitutes is fueled by growing worries about pollutants produced from serum, such as unpredictability and safety risks. Further supporting market expansion, innovation, and product creation are developments in biotechnology and cell culture methods. Further driving the market's rise is the growing need for uniformity and reproducibility in cell culture applications. In addition, the trend toward serum-free media is driven by ethical and regulatory concerns related to the usage of goods obtained from animals. Research institutions and industry entities working together create a dynamic environment of ever-evolving formulas and technologies and drive market competitiveness.


Global Serum-free Media Drivers

  • Advancements in Biotechnology

Researchers and manufacturers are searching for serum-free alternatives to conventional medium as biotechnological techniques advance, with the goal of improving control, reproducibility, and safety in cell culture applications. The development of complex serum-free formulations suited for different cell types and applications is made possible by these innovations, which meet the growing need for dependable and scalable cell culture methods in fundamental research, regenerative medicine, and the manufacturing of biopharmaceuticals.

  • Demand for Reproducibility

The market for serum-free medium is driven by the need for reproducibility, which is a top priority for companies and academics who want uniform and standardized cell culture results. Serum-free medium reduce variability and improve repeatability in experimental outcomes by providing a specified, controlled environment. The use of serum-free media meets the demand for reproducibility, which is essential for scientific research, drug discovery, and biomanufacturing procedures. This ensures dependable and uniform cell growth conditions across various trials, batches, and labs.



  • Transition Challenges

The logistical difficulties involved in making the move from serum-containing to serum-free formulations impede the adoption of serum-free media. Significant protocol modifications, experimental technique revalidation, and possible disruptions to established processes are all necessary for this transformation. Furthermore, to ensure compatibility with certain cell types or applications and optimize serum-free media formulations, specialized knowledge and resources are required. The general use of serum-free media is being delayed by these obstacles, which present problems for enterprises and researchers thinking about making the changeover.

  • Complex Formulations

Developing serum-free media formulations for particular cell types or applications necessitates a deep comprehension of growth factors, dietary requirements, and cell biology. The intricacy of the problem escalates the duration and expenses linked to formulating new formulations, hence impeding the expansion and marketing of products utilizing serum-free medium. Furthermore, these formulations' complexity can make them inaccessible to enterprises and researchers with little funding or experience.



  • Advancements in Stem Cell Research

The market for serum-free media is presented with prospects by developments in stem cell research, which drive the need for customized formulations that promote the growth and differentiation of different types of stem cells. The application of stem cell research in drug development, disease modeling, and regenerative medicine is driving the demand for serum-free media that are ideal for culturing pluripotent and multipotent stem cells in vitro. Manufacturers now have the chance to provide cutting-edge serum-free media products that meet the changing requirements of doctors and stem cell researchers.

  • Rising Demand for Animal-Free Products

The demand for serum-free media formulations that provide a workable substitute is rising as ethical and legal issues pertaining to the usage of sera produced from animals increase. The adoption of animal-free media is in line with ethical and sustainability concerns in a number of businesses, including biopharmaceuticals, biotechnology, and research. Producers can take advantage of this chance by creating and offering premium serum-free media solutions to satisfy the growing market need.


Segment Overview

  • By Product

Based on the product, the global serum-free media market is divided into CHO media, HEK 293 media, BHK medium, vero medium, stem cell medium, and other serum-free media. The CHO media category dominates the market with the largest revenue share in 2023. Serum-free medium formulations created especially for Chinese Hamster Ovary (CHO) cell development and maintenance are included in this category. In the manufacturing of biopharmaceuticals, CHO cells are frequently employed to express therapeutic proteins and monoclonal antibodies. Serum-free formulations known as HEK 293 media are designed specifically for the culture of Human Embryonic Kidney (HEK) 293 cells. Serum-free media specially designed for the cultivation of Baby Hamster Kidney (BHK) cells are referred to as BHK medium. African Green Monkey Kidney Epithelial Cells are the source of Vero cells, which are cultivated in the vero medium.

  • By Application

Based on the application, the global serum-free media market is categorized into bioproduction, vaccine production, tissue engineering & regenerative medicine, and cell and gene therapy. The bioproduction category leads the global serum-free media market with the largest revenue share in 2023. The large-scale cell culture used in bioproduction to produce biopharmaceuticals such recombinant proteins, monoclonal antibodies, and vaccines is suited for serum-free media. The development and proliferation of virus-infected cells or virus-like particles used in vaccine manufacture are optimized in serum-free medium. The development, differentiation, and functional maturation of distinct cell types used in tissue engineering constructions or regenerative therapies are supported by serum-free medium used in tissue engineering and regenerative medicine.

  • By End-user

Based on end-user, the global serum-free media market is segmented into pharmaceutical & biotechnology companies, research & academic institutes, and others. The pharmaceutical & biotechnology companies segment dominates the serum-free media market. Pharmaceutical companies, biotechnology companies, and biopharmaceutical manufacturers involved in medication discovery, development, and production make up this part of the serum-free media market. These businesses produce vaccines, conduct stem cell research, produce therapeutic proteins and monoclonal antibodies through bioproduction, and use serum-free media for a variety of purposes. Academic labs, research facilities, and universities make up a sizable portion of the market for serum-free media. To conduct basic research, disease modeling, drug screening, and stem cell investigations in a variety of scientific fields, such as molecular biology, cell biology, immunology, and regenerative medicine, these institutes use serum-free media.


Global Serum-free Media Overview by Region

The global serum-free media market is categorized into North America, Europe, Asia-Pacific, and the Rest of the World. North America emerged as the leading region, capturing the largest market share in 2023. With a large number of pharmaceutical and biotechnology businesses spearheading innovation and research in cell culture technologies, the region has a thriving biopharmaceutical industry. Furthermore, North America is home to internationally recognized academic institutions and research facilities that promote a culture of technical innovation and intellectual brilliance. Additionally, the region's adoption of serum-free media is aided by robust healthcare infrastructure, supportive government legislation, and significant investment in research and development.

Throughout the forecast period, Asia-Pacific is anticipated to post a significant CAGR. This prediction is supported by several variables, such as the region's growing biopharmaceutical industry, increased R&D spending, and growing use of cutting-edge cell culture methods. The region's growth potential is further enhanced by advantageous government efforts, expanding pharmaceutical industry outsourcing tendencies, and a substantial pool of highly qualified individuals. The need for serum-free media is also being driven by growing healthcare spending, better infrastructure, and a developing biotechnology sector, which positions Asia-Pacific as a major market growth engine.



Global Serum-free Media Competitive Landscape

In the global serum-free media market, a few major players exert significant market dominance and have established a strong regional presence. These leading companies remain committed to continuous research and development endeavors and actively engage in strategic growth initiatives, including product development, launches, joint ventures, and partnerships. By pursuing these strategies, these companies aim to strengthen their market position, expand their customer base, and capture a substantial share of the market.

Some of the prominent players in the global serum-free media market include,

  • Thermo Fisher Scientific Inc.
  • Sartorius AG
  • Merck KgaA
  • Lonza Group AG
  • Danaher
  • FUJIFILM Holdings Corporation
  • MP Bio medicals
  • Corning Incorporated
  • PAN-Biotech
  • R&D Systems, Inc., and various others.


Global Serum-free Media Recent Developments

  • In January 2023, The Singapore Food Agency (SFA) has granted a new, first-in-the-world regulatory license to GOOD Meat, the cultivated meat branch of Eat Just, Inc., for the use of serum-free media in the manufacture of cultivated meat.
  • In January 2021, Thermo Fisher Scientific used allogeneic procedures to create a novel medium for human T lymphocyte development and expansion for cell therapy producers.


Scope of the Global Serum-free Media Report

Serum-free Media Market Report Segmentation



By Product

  • CHO Media
  • HEK 293 Media
  • BHK Medium
  • Vero Medium
  • Stem Cell Medium
  • Other Serum-free Media

By Application

  • Bioproduction
  • Vaccines Production
  • Tissue Engineering & Regenerative Medicine
  • Cell and Gene Therapy

By End-user

  • Pharmaceutical & Biotechnology Companies
  • Research & Academic Institutes
  • Others

By Geography

  • North America (USA, and Canada)
  • Europe (UK, Germany, France, Italy, Spain, Russia and Rest of Europe)
  • Asia Pacific (Japan, China, India, Australia, Southeast Asia and Rest of Asia Pacific)
  • Latin America (Brazil, Mexico, and Rest of Latin America)
  • Middle East & Africa (South Africa, GCC, and Rest of Middle East & Africa)

Customization Scope

  • Available upon request


  • Available upon request


Objectives of the Study

The objectives of the study are summarized in 5 stages. They are as mentioned below:

  • Global Serum-free Media Market Size and Forecast: To identify and estimate the market size for the global serum-free media market segmented by product, by application , by end user, region and by value (in U.S. dollars). Also, to understand the consumption/ demand created by consumers of serum-free media between 2019 and 2032.
  • Market Landscape and Trends: To identify and infer the drivers, restraints, opportunities, and challenges for the global serum-free media market
  • Market Influencing Factors: To find out the factors which are affecting the sales of serum-free media among consumers
  • Impact of COVID-19: To identify and understand the various factors involved in the global serum-free media market affected by the pandemic
  • Company Profiling:  To provide a detailed insight into the major companies operating in the market. The profiling will include the financial health of the company's past 2-3 years with segmental and regional revenue breakup, product offering, recent developments, SWOT analysis, and key strategies.


Intended Audience

  • Pharmaceutical companies
  • Biotechnology firms
  • Biopharmaceutical manufacturers
  • Academic laboratories

Research Methodology

Our research methodology has always been the key differentiating reason which sets us apart in comparison from the competing organizations in the industry. Our organization believes in consistency along with quality and establishing a new level with every new report we generate; our methods are acclaimed and the data/information inside the report is coveted. Our research methodology involves a combination of primary and secondary research methods. Data procurement is one of the most extensive stages in our research process. Our organization helps in assisting the clients to find the opportunities by examining the market across the globe coupled with providing economic statistics for each and every region.  The reports generated and published are based on primary & secondary research. In secondary research, we gather data for global Market through white papers, case studies, blogs, reference customers, news, articles, press releases, white papers, and research studies. We also have our paid data applications which includes hoovers, Bloomberg business week, Avention, and others.

Data Collection

Data collection is the process of gathering, measuring, and analyzing accurate and relevant data from a variety of sources to analyze market and forecast trends. Raw market data is obtained on a broad front. Data is continuously extracted and filtered to ensure only validated and authenticated sources are considered. Data is mined from a varied host of sources including secondary and primary sources.

Primary Research

After the secondary research process, we initiate the primary research phase in which we interact with companies operating within the market space. We interact with related industries to understand the factors that can drive or hamper a market. Exhaustive primary interviews are conducted. Various sources from both the supply and demand sides are interviewed to obtain qualitative and quantitative information for a report which includes suppliers, product providers, domain experts, CEOs, vice presidents, marketing & sales directors, Type & innovation directors, and related key executives from various key companies to ensure a holistic and unbiased picture of the market. 

Secondary Research

A secondary research process is conducted to identify and collect information useful for the extensive, technical, market-oriented, and comprehensive study of the market. Secondary sources include published market studies, competitive information, white papers, analyst reports, government agencies, industry and trade associations, media sources, chambers of commerce, newsletters, trade publications, magazines, Bloomberg BusinessWeek, Factiva, D&B, annual reports, company house documents, investor presentations, articles, journals, blogs, and SEC filings of companies, newspapers, and so on. We have assigned weights to these parameters and quantified their market impacts using the weighted average analysis to derive the expected market growth rate.

Top-Down Approach & Bottom-Up Approach

In the top – down approach, the Global Batteries for Solar Energy Storage Market was further divided into various segments on the basis of the percentage share of each segment. This approach helped in arriving at the market size of each segment globally. The segments market size was further broken down in the regional market size of each segment and sub-segments. The sub-segments were further broken down to country level market. The market size arrived using this approach was then crosschecked with the market size arrived by using bottom-up approach.

In the bottom-up approach, we arrived at the country market size by identifying the revenues and market shares of the key market players. The country market sizes then were added up to arrive at regional market size of the decorated apparel, which eventually added up to arrive at global market size.

This is one of the most reliable methods as the information is directly obtained from the key players in the market and is based on the primary interviews from the key opinion leaders associated with the firms considered in the research. Furthermore, the data obtained from the company sources and the primary respondents was validated through secondary sources including government publications and Bloomberg.

Market Analysis & size Estimation

Post the data mining stage, we gather our findings and analyze them, filtering out relevant insights. These are evaluated across research teams and industry experts. All this data is collected and evaluated by our analysts. The key players in the industry or markets are identified through extensive primary and secondary research. All percentage share splits, and breakdowns have been determined using secondary sources and verified through primary sources. The market size, in terms of value and volume, is determined through primary and secondary research processes, and forecasting models including the time series model, econometric model, judgmental forecasting model, the Delphi method, among Flywheel Energy Storage. Gathered information for market analysis, competitive landscape, growth trends, product development, and pricing trends is fed into the model and analyzed simultaneously.

Quality Checking & Final Review

The analysis done by the research team is further reviewed to check for the accuracy of the data provided to ensure the clients’ requirements. This approach provides essential checks and balances which facilitate the production of quality data. This Type of revision was done in two phases for the authenticity of the data and negligible errors in the report. After quality checking, the report is reviewed to look after the presentation, Type and to recheck if all the requirements of the clients were addressed.

Frequently Asked Questions

On the basis of Geography, the serum-free media market is classified into North America, Europe, Asia Pacific, and the Rest of the world.
According to serum-free media market research, the market is expected to grow at a CAGR of ~13.5% over the coming years.
Asia-Pacific is expected to register the highest CAGR during 2024 - 2032
North America held the largest share in 2023
The major players operating in the global market include Thermo Fisher Scientific Inc.; Sartorius AG; Merck KgaA; Lonza Group AG; Danaher; FUJIFILM Holdings Corporation; MP Bio medicals; Corning Incorporated; PAN-Biotech; R&D Systems, Inc. , and various others.

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